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Beneficial effects of Gln supplementation on some cardiovascular risk factors have also been reported in animals exposed to exercise or a high-fat diet [33,34,35]

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Upon its accumulation and phosphorylation, HIF-1 dimerizes with HIF- (constitutively expressed nuclear proteins), enters the nucleus, and promotes the transcription of hypoxia response elements (HRE)-containing target genes involved in energy metabolism, erythropoiesis, vascular remodelling, and other processes (Fig

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