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As previously determined, antigen-presenting cells that are actively engaged (such as dendritic cells) are the primary origin of IL-12, 23, that trigger Th1,17 [97]

748 Inhibition of this pathway using the PAR1 antagonist vorapaxar has been shown to reduce the burden of senescent cells, offering a potential therapeutic strategy

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Heteromers DR-DR Heteromers D1-D2R Heteromers Activation of the Gq-coupled D1-D2R heteromers in striatal neurons results in PLC-dependent intracellular calcium release, thus activating calmodulin-dependent protein kinase II (CaMKII)/Mutations of the methyl-CpG binding protein 2 (MeCP2)/brain-derived neurotrophic factor (BDNF) pathway (49)