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Berberine, a mitochondrial-targeting compound, can inhibit PINK1 promoter hypermethylation and enhance PINK1 expression, thereby promoting autophagy-lysosome pathway and alleviating mitochondrial dysfunction in AD models (Wang et al., 2023)

Acknowledgements The authors are grateful to the Fundao de Apoio Pesquisa do Estado da Paraba (FAPESQ, Brazil) for the scholarships awarded to L.C.P.d.N and D.C.L

Kisspeptin Synchronizes Preovulatory Surges in Cyclical Ewes and Causes Ovulation in Seasonally Acyclic Ewes

Protects cells from oxidative stress and promotes skin health

Here, we benchmarked several engineered laccase templates 22,23,24,25 , identified an ancestral fungal variant with slight activity in HEK293T cells and performed extensive directed evolution on the yeast surface to improve its activity (Fig