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To understand if the product can cause irritation to your skin when paired with other products and to understand the compatibility of different ingredients used for different skin concerns

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This stimulatory effect can be blocked by pretreatment with the p38 inhibitor SB203580, the PI3 kinase inhibitor wortmannin or the MEK1/2 inhibitor U0126 [310]

Both work as excretory forces against a relatively weaker absorption force, ie, capillary osmotic pressure (+20 mmHg)