In a 2022 review of 21 placebo-controlled randomized trials that tested a broad swath of purported hangover-prevention ingredients, researchers concluded only very low quality evidence of efficacy is available to recommend any pharmacologically active intervention for the treatment or prevention of alcohol-induced hangover. What causes hangoversand can these products really do anything about it
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10.2147/JIR.S434226 69 MaoC.LiuX.ZhangY.LeiG.YanY.LeeH.et al (2021)
The absence or diminished function of ATP7B results in accumulation of copper in the hepatocyte due to both impaired copper excretion into bile and inability to incorporate copper into ceruloplasmin.14 The production of ceruloplasmin without attached copper (apoceruloplasmin), which has a shorter half-life than ceruloplasmin, results in decreased levels of ceruloplasmin in the blood of Wilsons patients
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