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Research shows Dihexa increases dendritic spine density by 40-50% in hippocampal neurons, with these new spines demonstrating functional characteristics of mature synapses including colocalization with presynaptic markers synapsin and VGLUT1, and generation of enhanced excitatory postsynaptic currents

Kautz, et al

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Increased excitability also increases the glutamate/glutamine neurotransmitter cycle flux as well as release of K + associated with pre and post synaptic depolarization and uptake of K + by the astrocytes