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Smoking has also emerged as a major risk factor for hepatocellular carcinoma (HCC) in PBC, with current smokers showing more than a twofold increased risk of HCC (adjusted HR: 2.31

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All qRTPCR assays were performed on the QuantStudio 5 Real-Time PCR system (Applied Biosystems, CA, USA) with Power-Up SYBR Master Mix (Applied Biosystems, CA, USA)

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