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Randomization and Masking Participants were randomized (3:1:3:1:3:1) to semaglutide (2, 8, or 16 mg s.c.) or matching placebo, with stratification by HbA 1c at screening ( 8.5% [69 mmol/mol]), applied from weeks 12 to 40, allowing time for dose escalation and effects from treatment

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