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Continued treatment with Tirzepatide for maintenance of weight reduction in adults with obesity: the SURMOUNT-4 randomized clinical trial

Important Note: As a long-acting amylin analog, Cagrilintide's action of slowing gastric emptying is believed to contribute directly to the high incidence of early-stage nausea and fullness

Ilarregui JM, Kooij G, Rodrguez E, van der Pol SMA, Koning N, Kalay H, et al

Additional mechanisms of action include delayed gastric (stomach) emptying which slows down the motility of the digestive tract making you feel full

The peptide fraction is deliberately small: only molecules under roughly 10 kilodaltons survive the process, with free amino acids making up the bulk of the rest