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The retarded leaching of nanoclusters can be attributed to their large size in comparison with molecular dyes and it is a clear advantage for imaging purposes as dye leaching decreases the fluorescence brightness of NPs and increases the background signal resulting in unfavorable imaging inefficiency/artifacts 50

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These in silico findings complement in vivo data and reinforce the concept that medicinal plants exert therapeutic effects through modulation of multiple molecular pathways rather than single-target mechanisms

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