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GLP-1 is quickly degraded by the dipeptidyl peptidase 4 (DPP-4) enzyme, making the plasma half-life 1-2 minutes
Some prefer morning injections because nausea is less bothersome when they are active
In the preclinical characterization, GLP-1R engagement was confirmed through glucose-tolerance, food-intake, and gastric-emptying readouts, and by loss of specific effects in GLP-1R knockout mice
When diversity drops, the ecosystem becomes more fragile and more susceptible to disruption from stress, dietary changes, antibiotics, or illness