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Such vascular responses are particularly relevant in experimental models of ischemia, where enhanced circulation contributes to tissue preservation and recovery.(22) In addition to its effects on vascular growth, it has been associated with regulation of vascular tone through interactions with nitric oxidedependent signaling mechanisms

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After years of research, it has now been shown that a deficiency of the vitamin leads to an increase in myelin-damaging cytokines and a decrease in myelin-promoting cytokines (34)