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Food and Drug Administration (2024) Update on FDAs ongoing evaluation of reports of suicidal thoughts or actions in patients taking a certain type of medicines approved for type 2 diabetes and obesity

Administration Details Retatrutide is administered via subcutaneous injection once weekly

She et al., 2024) and blocks cortical neuronal oxidative damage by suppressing the p53-mediated Bcl-2/Bcl-2-associated X protein (Bax)/Caspase-3 apoptosis pathway and regulating the Kelch-like ECH-associated protein 1 (Keap1)/Nrf2 pathway, thus playing a pivotal role in reducing neuroinflammation (Yang C

Pregnancy planning, lactation, or recent thyroid hormone dose changes also warrant provider consultation before GLP-1 start

J Mol Endocrinol 64(1):2942 Bachem A, Makhlouf C, Binger KJ, de Souza DP, Tull D, Hochheiser K et al (2019) Microbiota-derived short-chain fatty acids promote the memory potential of antigen-activated CD8+ T cells