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Moreover, the resistance of PLGA nanoparticles encapsulating DDA-GSH-AuNCs to photobleach upon continuous laser irradiation was evaluated in comparison with conventional fluorescent dyes: Nile red and fluorescein (relatively stable and labile dyes to photobleaching, respectively) 51

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Additionally, free heme can generate the reactive nitrogen species peroxynitrite that can further oxidative stress 61