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In the case of renal impairment, urinary elimination of carnitine increasing, endogenous synthesis decreasing, and poor nutrition as a result of disease-induced anorexia can result in carnitine deficiency

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Whilst L-cell signalling to neighbouring enterocytes via PYY is believed to play a role in volume homoeostasis, the potential physiological importance of the transient I sc elevation attributable to L-cell released ATP is currently unclear