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Other side effects are dry skin and lips, muscle and joint pain, headache, higher triglyceride levels (a type of cholesterol), higher liver enzymes, decline in night vision, and, rarely, temporary hair shedding

The most commonly used approach is in vitro or ex vivo tests using diffusion cells, or more recently, the parallel artificial membrane permeability assay (Skin-PAMPA) and phospholipid vesicle-based permeation assay (PVPA) (Figure 4) [40], allowing for the quantification of the permeation of CACs through the skin