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Specific criteria include a BMI of 35 kg/m or above (or lower in certain ethnic groups), problems associated with high weight, or if insulin would otherwise be initiated but presents significant occupational implications

In formulating a controlled-release formulation, it is advised to avoid or combine the appropriate excipients, diluents or carriers to lessen or eliminate potential ototoxic components from the formulation, or to decrease the amount of such excipients, diluents, or carriers

Clinical trials demonstrated significant improvements in insulin sensitivity, hemoglobin A1c levels, blood pressure, and lipid profilesall factors that influence reproductive health