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In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist

Cell Stem Cell 14 , 810823 (2014)

In fact, taking a prescription medication in a way other than intended (for instance, someone using another persons medication, or taking a higher dose than prescribed) can lead to serious health effects , including overdose, dependency, or other harmful reactions

It is about the combination of temperature and time

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