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Over-expression of miR-17-92 in HUVECs can protect ECs from erastin-induced ferroptosis by targeting the zinc lipoprotein (A20)-acyl-CoA synthetase long-chain family member 4 (ACSL4) axis that could protect glutathione peroxidase 4 (GPX4) and inhibit ROS production (Xiao et al., 2019)
Incidence Estimates A large Danish cohort study (N=25,906 isotretinoin users, follow-up through national registries) published in the BMJ (2019) found no statistically significant increase in depression diagnoses or antidepressant prescriptions after isotretinoin initiation compared with oral antibiotic controls, with a hazard ratio of 0.99 (95% CI 0.91 to 1.07)
Therapy, medicine or both may help
[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Wen M, Zhou B, Chen YH, et al