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Older GH secretagogues tended to drag the hypothalamic-pituitary-adrenal axis along with the GH axis, raising stress hormones as an off-target consequence

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7, 8, 9, 10, 11 Gene-deficient knockout mouse models have not only confirmed the importance of cytokines and growth factors but also revealed the role of metabolic networks in integrating regenerative response with maintenance of hepatic function