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After deduplication and standardization, the final UC-related targets were obtained

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Amoeboid cells exhibit weak adhesions, show high dependence on actomyosin contractility, and utilize spherical bulges known as membrane blebs for efficient migration, invasion, and extravasation [166,167,168]

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Compared with GPX1-3, GPX4 is also involved in the reduction of complex membrane-associated phospholipid hydroperoxides such as phosphatidylcholine hydroperoxide and cholesterol hydroperoxide, in addition to reacting with soluble, low molecular weight hydroperoxides such as t-butyl hydroperoxide and cumene hydroperoxide [68]