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They are water-soluble which just means that if there's anything in excess, it will be just excreted through urine or bile

Niacinamide (B3) and Vitamin C act as powerful antioxidants to reduce the risk of formation of pigmentation and boost skin look

Apart from amelioration of MDA and ROS, PQQ also increased the activity of SOD, a major mitochondrial antioxidant enzyme that converts toxic superoxide to hydrogen peroxide

A recent FDA 503A update in the U.S

In a small, randomized, open-label trial in 38 women of reproductive age receiving 30 weeks of daily multivitamin supplements, daily supplementation with either 1.1 mg or 5 mg of folic acid resulted in the transient appearance of unmetabolized folic acid in blood over the first 12 weeks of supplementation (213)