A widely used research tool for studying IGF-1 receptor (IGF-1R) signal transduction including PI3K/Akt pathway activation, MAPK/ERK phosphorylation cascades, and downstream transcription factor engagement in IGF-1R-expressing cell lines
The principles of sterility, gentle handling, and accurate measurement are universal
Its gentle profile makes it popular for lean-muscle preservation during calorie deficits
Cancer-pathway concern IGF-1 signaling is mitogenic and anti-apoptotic, two properties relevant to cancer biology
Gondo et al, Growth Hormone-Releasing Peptide-2 Stimulates GH Secretion in GH-Deficient Patients with Mutated GH-Releasing Hormone Receptor, The Journal of Clinical Endocrinology & Metabolism, Volume 86, Issue 7, 1 July 2001, Pages 32793283, Mericq V, Cassorla F, Salazar T, Avila A, Iiguez G, Bowers CY, Merriam GR