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Long-term metformin treatment is able to reduce the prevalence of metabolic syndrome and its hepatic involvement in young hyperinsulinaemic overweight patients with polycystic ovarian syndrome

showed that DEX increased the expression levels of SLC7A11 and GPX4 and protected H9C2 cells from hypoxia/reoxygenation injury through the AMPK/GSK-3/Nrf2 axis [233]

these activities of carvedilol-bound 2 AR are further counteracted by MARCH2 binding, ubiquitination and 2 AR degradation ensuring long-term desensitization [102]

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2012;302(2):G260266