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Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase

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Specifically, ammonium stimulates sterol regulatory element-binding protein (SREBP) cleavage, enhancing nuclear translocation and upregulating fatty acid synthase (FASN) and stearoyl-CoA desaturase 1(SCD1)