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This gradual titration protocol begins at 50 mg daily to assess tolerance, as starting too high can produce adverse reactions such as insomnia, anxiety, or fatigue [4]

Moderate to severe liver disease: Maximum recommended dose is Wellbutrin XL 150 mg every other day, or Wellbutrin SR 100 mg once daily, or bupropion (immediate release) 75 mg once daily

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The combined treatment of LC and TAU was more effective than that of LC or TAU alone on suppressing the proliferation and osteoblastic differentiation in VSMCs