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The consequence of obesity is not limited to the risk of developing cardiovascular diseases but also include the possibility of male fertility impairment (Figure 4)

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Following this stage of development as a junctional nevus, further cellular development and proliferation results in the migration or dropping off of nevus cells and their organization into nests within the papillary dermis (compound nevus)

These effects are mediated through GLP-1 receptors (GLP-1R), which are widely distributed throughout the body, including the pancreas, liver, skeletal muscle, gastrointestinal tract, cardiovascular system, and central nervous system

M.VillmannC.et al (2018)