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The study authors themselves concluded that these findings "provide reassurance that a greater proportion of lean mass is not lost with retatrutide despite the overall increased weight loss." When researchers who designed the trial reach that conclusion, it carries significant weight

9.3%), and later-onset T2DM ( n =1,815

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Additionally, GLP-1 agonists suppress glucagon secretion from pancreatic alpha cells, slow gastric emptying, and promote satiety through central nervous system effects, contributing to weight loss in many patients