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In vitro experiments and in vivo studies employing animal models have demonstrated that SCFA supplementation elevates the transcriptional expression of TRPV6 and calbindin-D9k in both human colonic epithelial (Caco-2) cells and the colonic mucosa of rats (108, 185)

Administered correctly at the right dose and timing

Both discoidal HDL particles and mature spherical HDL particles can also promote free cholesterol efflux from another transporter, ATP-binding cassette transport G1 (ABCG1), which is thought to reside on sub-cellular organelles as opposed to the plasma membrane (Figure 2) (690,691)

Guthikonda S, Sinkey C, Barenz T, Haynes WG

2021 Nov