10.1371/journal.pgen.1000504 PLoS Genet
Searches were conducted using combinations of keywords and Medical Subject Headings (MeSH) terms related to incretin-based therapies and obesity, including GLP-1 receptor agonists, dual agonists, triple agonists, liraglutide, semaglutide, tirzepatide, mazdutide, retatrutide, adolescent obesity, and pediatric obesity
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Developed by Theratechnologies Inc., it underwent phase II trials in the mid-2000s for GH deficiency (GHD) and HIV lipodystrophy but was discontinued, with reported reasons including hypersensitivity reactions, including an anaphylaxis-like reaction in one trial participant Wong et al (2008) [Note: Abstract only
What makes tesamorelin and retatrutide theoretically complementary