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It is naturally produced by the body and also found in certain foods

Chl content and ALA-synthesizing capacity consistently remained wild-type-like ( Supplementary Figures 3B, C ) with the striking exception of GSAAT(C190S), which exhibited a significantly lower rate of ALA synthesis

In general, phase I metabolizing enzymes catalyze reactions that increase the reactivity of hydrophobic (fat-soluble) compounds, preparing them for reactions catalyzed by phase II biotransformation enzymes

For example, the inhibition of ferroptosis may reduce the activation state of DCs, thereby diminishing their ability to activate Th17 cells (157)