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Mean diabetes duration ranges from 5.2 2.8 years (Mokhtari et al., 2021) to 15.3 4.1 years ( 5.6.4 Endpoint selection and standardization Across the 12 RCTs, seven different primary endpoints were used (VAS, TCSS, NDS, VPT, NSS, SNAP, SNCV), and only two trials adopted composite scores recommended by the Toronto Consensus on Diabetic Neuropathy (Pop-Busui et al., 2017)

In addition, NMDAR1 and slightly NMDAR2 mRNA levels increased, while AMPAR1 level decreased in the L-carnitine-treated group

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(2015) Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, Br

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