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3.6 Anti-inflammatory effects of GO@GSH-FA in OGD/R-induced SH-SY5Y cells To elucidate the potential anti-inflammatory role of GO@GSH-FA in ischemia-induced cellular damage, we quantitatively assessed the levels of key proinflammatory cytokines, namely Tumor Necrosis Factor- (TNF-) and, Interleukin-1 (IL-1) in SH-SY5Y cells subjected to oxygen-glucose deprivation and reoxygenation (OGD/R) and treated with GO@GSH-FA

These remarkable findings are transformative to kidney care, support the increase in utilization these agents for suitable patients, and encouraged continued work on defining benefits to wider kidney patient populations

(2) Saponins: Astragaloside IV, an active component of Astragalus, activates the PI3K/AKT and Nrf2 signaling pathways, reduces oxidative stress, enhances GPX4 and Nrf2 expression, reduces iron accumulation, inhibits ferroptosis induced by Aflatoxin, significantly improves kidney damage, and protects kidney cells (178)

Am J Physiol Endocrinol Metab 305:E243253 Du Y, Carranza Z, Luan Y, Busman-Sahay K, Wolf S, Campbell SP, Kim SY, Pejovic T, Estes JD, Zelinski M et al (2022) Evidence of cancer therapy-induced chronic inflammation in the ovary across multiple species: a potential cause of persistent tissue damage and follicle depletion

The function of this protein is not well understood