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Remarkably, a study by Escribano et al revealed that, when compared with the control group, children with severe AATD showed significantly increased levels of oxidative stress biomarkers and decreased levels of antioxidants, as expressed by lower total and reduced glutathione levels, decreased catalase activity, and increased glutathione peroxidase activity

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This structure strictly regulates the passage of substances from the bloodstream into the brain, allowing essential nutrients while preventing the entry of toxins and pathogens