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Since reduced anti-coagulant properties and increased pro-inflammatory mediators and reactive oxygen species play important roles in the development of both endothelial dysfunction and atherosclerosis, the association between the two is almost ubiquitous [88]
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& Odutuga, A
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This benefit is putatively driven by the systemic amelioration of metabolic risk factors like high body mass index (BMI) and hyperlipidemia, though direct preclinical evidence remains lacking
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