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1999 Oct 29;148(2):1119

Kesler A, Kliper E, Shenkerman G, Stern N

Although the SAVOR and EXAMINE studies were delineated to verify cardiovascular safety of two DPP-4i, namely saxagliptin and alogliptin, respectively, both are considered to be the first controlled clinical trials to address the effect of GLP-1 system on CVD

To advance this field, more refined and tissue-selective strategies are under investigation, including minimally invasive delivery systems and prodrugs engineered to become active exclusively within senescent microenvironments

Phase I metabolism of Dkhexa was investigated using pooled rat liver microsomes