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Metabolic imbalances, especially in lipid and glucose metabolism, are often accompanied by increased ROS, leading to oxidative stress that further damages the vascular endothelium, inhibits NO production, and impairs vascular regulation [262, 263]

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

Epub 2019 Oct 21

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Surveys across various regions in China among adults aged 1865 years show an annual prevalence of headache as 28.5%, with most cases being primary migraines frequently seen in middle-aged women (Yu et al., 2013, 2012, 2011)