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This decrease leads to many of the symptoms we identify as aging

The Phase 2 trial specifically tested starting at 4mg versus 2mg and found that higher starting doses produced significantly more GI side effects without faster weight loss

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IGF-1/IGF-1R knockout mice showed decreased brain size, loss of myelination, and cognitive decline, whereas overexpression of IGF-1 resulted in increased brain size and myelination [32]