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AZs small-molecule GLP-1R agonist (licensed from Chinas Eccogene) hit Phase 2 endpoints and is moving into Phase 3

Small, frequent meals may be better tolerated than larger meals given the delayed gastric emptying associated with these medications

4.1 The ApelinAPJ axis Apelin was identified as the endogenous ligand for the APJ receptor, a G proteincoupled receptor structurally related to the angiotensin II type 1 receptor but functionally distinct from the reninangiotensin system ( Despite these favorable metabolic effects, enthusiasm for apelin-based therapeutics waned due to its potent cardiovascular actions, including vasodilation and positive inotropy

Tsai, Y.-C

Serve with a small mashed sweet potato (no butter, use splash of almond milk)