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Abnormal activation of the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has been associated with the onset of several inflammatory diseases, promoting various types of cell death, including apoptosis, necroptosis, and ferroptosis [178]

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Amphastar Pharmaceuticals' nasal spray Rextovy (naloxone hydrochloride) has been approved as the first over-the-counter intranasal emergency treatment for opioid overdose

PRDM1 promotes the ferroptosis and immune escape of thyroid cancer by regulating USP15-mediated SELENBP1 deubiquitination