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Mostly, vitamin B12 is advised to be taken in the morning or with a meal, since it is associated with energy metabolism, which may interrupt your sleep if taken at night

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While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimers disease

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