Current trials are considering the effectiveness, efficacy, tolerance, and safety of a much higher dose of semaglutide: 7.2 milligrams instead of 2.4
Tirzepatide users saw even more impressive results, with average weight loss reaching 15-20% of their body weight in some trials
These drugs, originally developed to manage diabetes, are now being widely prescribed for weight loss, but also come with the unexpected side effect of boosting fertility
The findings deliver early evidence that semaglutide may offer a dual benefit, targeting obesity and key reproductive challenges associated with the condition, including irregular menstruation and impaired fertility. Clare Thompson, MBBS, BSc, nMRCGP Separately, a review of five randomized controlled trials presented at ENDO 2026 found that GLP-1 drugs, such as semaglutide and liraglutide, do not appear to harm male fertility and may even improve testosterone levels and sperm quality in some men with obesity
Individuals with known or suspected fertility issues should consider evaluation before starting semaglutide, establishing baseline reproductive function