A 2017 review summarised neuroprotective properties of silymarin in animal models, including: Reduction of amyloidogenic activity (relevant in Alzheimer's research) Anti-inflammatory action in nerve tissue Reduction of oxidative stress in the brain Possible positive effects on cognitive function Possible reduction of stroke risk Whether these effects can be achieved in humans at attainable concentrations of silymarin in particular whether sufficient quantities can cross the blood-brain barrier remains unclear
& Vennstrm, B
Adrenal fatigue is the negative effect of experiencing chronic stress that puts your adrenals on overdrive for extended periods of time
34 However, in a placebo-controlled trial in 99 subjects with PCOS, 12 weeks of treatment with a synbiotic supplement providing the prebiotic inulin plus a combination of seven probiotic strains improved LDL- and high-density lipoprotein (HDL)-cholesterol levels, but did not alter triglyceride levels, body weight, or body composition
The mechanisms most cited in the literature are promotion of angiogenesis (new blood-vessel formation, linked to VEGFR2 signaling), modulation of growth-factor and nitric-oxide pathways, and interaction with the gut-brain axis
