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Exendin-4-C16 was previously shown to be detectable in plasma 72 hours after dosing (Lucey et al ., 2020)

Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1

Energy-dispersive X-ray spectroscopy (EDX) was performed on a Tecnai G2 F30 TEM (Philips, Eindhoven, Netherlands) equipped with a 300 kV acceleration voltage for analyzing the elemental composition of the samples

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Cyanocobalamin : It is a synthetic form of Vitamin B12 which is used in the production of red blood cells and the functioning of nerves