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In the early adhesion phase, immune defenses are active: neutrophils and M1 macrophages target bacteria via phagocytosis, oxidative bursts, increased antimicrobial peptides (AMPs), reactive oxygen species (ROS), and pro-inflammatory cytokines (IL-1, IL-6, TNF-) and chemokines

Several preclinical and limited numbers of clinical studies have indicated that mitochondria can be a potential and robust target for the amelioration of clinical symptoms of ASD

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Instead of only allowing fully digested nutrients to pass through, the compromised barrier allows endotoxins (such as lipopolysaccharides, or LPS, from the cell walls of gram-negative bacteria), undigested food proteins, and microbial fragments to "leak" directly into the bloodstream