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Description

The compound incorporates three non-standard structural features: an -aminoisobutyric acid (Aib) at the N-terminus bearing no stereocenter, a D-2-naphthylalanine (D-2-Nal) at position 3, and a D-phenylalanine at position 4

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IGF Binding Proteins and Bioavailability The mechanism underlying this enhanced potency relates to IGF-1's complex regulatory system involving IGF binding proteins (IGFBPs), a family of six high-affinity binding proteins (IGFBP-1 through IGFBP-6) that normally sequester the vast majority of circulating IGF-1 and regulate its bioavailability, half-life, and access to cell surface IGF-1 receptors

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In continuation selenium compounds in 2004 Back and co-workers reported for the first time that spirodioxyselenurane and its tellurium analogue exhibit very good antioxidant activity by mimicking the glutathione peroxidase (GPx) enzyme which protects the organism from oxidative damage by catalyzing the reduction of peroxides using thiol as the cofactor [47, 56]

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