As an example of such a multipronged approach, the Neotone formulation simultaneously targeting melanocytes, fibroblasts, and endothelial cells with the combination of five actives (niacinamide, licorice extract, diacetylboldine, a DKK1 agonist, and an inhibitor of EDN-1 synthesis) was found to be as effective as hydroquinone 4% cream in the management of facial melasma, while inducing fewer side effects [214]
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If heterogeneity was detected, a random-effects model was used
Key Objectives of GMP The key objectives of GMP are to minimize the risks involved in any pharmaceutical production that cannot be eliminated through testing the final product