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Similarly, in real-world settings, a Korean cohort study involving 358,862 participants showed that SGLT2 inhibitors reduce the risks of dementia and PD in T2DM patients [147]

The combo adds gastrointestinal cytoprotection, fibroblast-specific FAK-paxillin signaling in tendons, and local IGF-1 / GH-R axis potentiation

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However, DPP-IV enzymes inactivate these incretins by breaking them down, which reduces insulin secretion and increases glucagon release, resulting in elevated blood glucose levels [161]