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T., Mazur M., Telser J

Although it has been shown that all FOXO isoforms bind to the same consensus sequences, subtle differences in the environment of the enhancer and promoter elements might still influence the preferential binding of specific FOXO isoforms to target genes

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3.1.2.2 G-protein coupled receptor pathway suppression EEDs systematically suppress GPCR-mediated signaling cascades essential for steroidogenesis and germ cell proliferation

My understanding ( not a scientist or doctor) Is liver stores run down slowly ovef years for many many reasons