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Induction of HO-1 reduced inflammatory cytokines, such as TNF- and IL-6, increased antioxidants, and improved angiogenesis in wound tissues of diabetic rats, thereby wound healing was accelerated in the diabetic state [118]

In batch culture process, the recombinant strain W303-1b/FGP also kept high efficiency in GSH production and reached an intracellular GSH content of 2.27 % after 24-h fermentation

The lack of balance between the production of ROS and the antioxidant defense system of animals will lead to DNA hydroxylation, protein denaturation, lipid peroxidation, cell apoptosis, ultimately lead to cell damage ( It has been found that the thioredoxin reductase system and glutathione peroxidase system play an important role in cellular oxidative stress defense ( 2- ), H 2 O 2 , and hydroxyl radicals (OH )

Garca-Caballero, M

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